| Disease | Psoriasis |
| Pathogenesis | Genetic factors - HLA-B13,HLA-B17, HLA-Bw57, HLA-Cw6 increased Environmental factors - physical injury, infection, drugs Abnormal cellular proliferation of keratinocytes microcirculatory changes - "bridged" fenestrations, neutrophils at tipsof dermal papillae, dec cAMP Immunologic factors - T cell infiltration |
| Pathology | thickened epidermis -hyperkeratosis + parakeratosis uniformally elongated rete ridges and dermal papillae dilated and tortuous capillaries of papillae epidermal hyperplasia Munro microabscesses - dense collection of neutrophils |
| ClinicalFeatures/Treatment | large, erythematous, scalyplaques dorsal extensor cutaneous surfaces 7% - seronegative arthritis, mild neutrophilic pustules T - coal tar or wood tar, anthralin, corticosteroids, methotrexate,vitamin A, vitamin D |
Saturday, May 07, 2005
Psoriasis
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